Azactam aztreonam for injection, usp should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Highlights of prescribing information deterioration. Each 50 ml of solution contains 1 g, or 2 g aztreonam with approximately 1. The pharmacy bulk package is for preparation of solutions for iv infusion only. Azactam will be injected directly into your vein over 35 minutes or it will be administered as an infusion over 30 minutes. Azactam injection aztreonam dose, indications, adverse. Extravascular concentrations susceptible breakpoint for aztreonam. Upon the addition of the diluent the contents should be shaken immediately and vigorously. The monobactams, having a unique monocyclic betalactam nucleus, are structurally different from other betalactam antibiotics eg, penicillins, cephalosporins, cephamycins.
The contents of an azactam aztreonam for injection, usp 15 ml capacity vial should be constituted with 6 ml to 10 ml sterile water for injection, usp. Please also see full prescribing information for azactam aztreonam for injection, usp on page 6. Single 30minute intravenous infusions of 500 mg, 1 g, and 2. Azactam warnings and precautions antibiotics home page. It may occur as early as the first week after start of therapy. In some people, azactam can cause a serious skin reaction called toxic epidermal necrolysis. Azactam information, side effects, warnings and recalls. Azactam aztreonam injection the structural difference.
Aqueous solutions of the product have a ph in the range of 4. Abelcet consists of amphotericin b complexed with two phospholipids in a 1. Azactam aztreonam dosing, indications, interactions. The serum levels of aztreonam following single 500 mg or 1 g intramuscular or intravenous or 2 g intravenous doses of aztreonam exceed the mic 90 for neisseria sp. Unasyn dry powder is freely soluble in aqueous diluents to yield pale yellow to yellow solutions containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin per ml and 125 mg sulbactam per ml.
Azactam 1g powder for solution for injection or infusion. Azactam for injection 1 g or 2 g vial are supplied in 15 ml vials. Azactam is a medication prescribed to treat a number of bacterial infections. Compare prices, print coupons and get savings tips for azactam aztreonam and other skin infection, urinary tract infection, bacterial infection, lower respiratory infection, and gastrointestinal infection drugs at cvs, walgreens, and other pharmacies. Dailymed azactam aztreonam injection, powder, for solution. Urinary tract infections complicated and uncomplicated, including pyelonephritis and cystitis initial. Jan 31, 2019 azactam for injection 1 g or 2 g vial are supplied in 15 ml vials. Description azactam aztreonam for injection, usp contains the active ingredient aztreonam, a monobactam. Open glass aztreonam vial by removing metal ring and pulling tab, and removing gray rubber stopper. Azactam can also be administered as an injection into a large muscle. Following constitution, the product is for intramuscular or intravenous use. Unasyn, ampicillin sodiumsulbactam sodium parenteral combination, is available as a white to offwhite dry powder for reconstitution. Dailymed aztreonam injection, powder, lyophilized, for.
Azactam in galaxy plastic container package insert. The range of average concentrations for aztreonam in the 8to 12hour urine specimens in these studies was 25 to 120 mcgml. Cayston is administered by inhalation using an altera nebulizer system. The dosage is based on your medical condition and response to therapy. Many of the serious infections have occurred in patients on concomitant immunosuppressive therapy which, in addition to their underlying disease, could further predispose them to infection. Prescribing information cubicin daptomycin for injection. Azactam solutions at concentrations exceeding 2% wv, except those prepared with sterile water for injection, usp or sodium chloride injection, usp, should be used promptly after preparation. Azactam and other antibacterial drugs, azactam should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Vials of reconstituted azactam are not intended for multidose use, and any unused solution from a single dose must be discarded. Orencia may be used as monotherapy or concomitantly with diseasemodifying, antirheumatic drugs dmards other than tumor. Please also see full prescribing information for azactam. Avoid excessive heat above 104 degrees f discard product if it contains particulate matter, is cloudy, or discolored store at controlled room temperature between 68 and 77 degrees f store in original package until time of use cayston. Bactroban cream mupirocin calcium cream, 2% contains the dihydrate crystalline calcium hemisalt of the antibiotic mupirocin. Asmanex twisthaler is a dry powder for inhalation that is available in 2 strengths.
Intravenous infusion solutions of azactam not exceeding 2% wv prepared with sodium chloride injection, usp 0. Azactam 2 g powder for solution for injection or infusion. Each vial contains 50 mg of amphotericin b, usp, intercalated into a liposomal membrane consisting of approximately 0. Treatment of bone and joint infections including osteomyelitis or septic arthritis caused by susceptible gramnegative bacteria, including enterobacter, escherichia coli, haemophilus influenzae, klebsiella, proteus mirabilis, pseudomonas aeruginosa, or. However, of aztreonam after a single the efficacy of aztreonam in treating clinical. Description azactam aztreonam injection contains the active ingredient aztreonam, a monobactam. Aortitis has been reported in patients receiving filgrastim products. How to use azactamisoosmotic dextrose solution, piggyback premix frozen. Oct 11, 2019 a tissue penetration is regarded as essential to therapeutic efficacy, but specific tissue levels have not been correlated with specific therapeutic effects the concentration of aztreonam in saliva at 30 minutes after a single 1 g intravenous dose 9 patients was 0. Manifestations may include generalized signs and symptoms such as fever, abdominal pain, malaise, back pain, and increased inflammatory markers e. It was originally isolated from chromobacterium violaceum.
Welcome to the information on this site is intended for health care professionals in the united states, its territories, and puerto rico and is not intended for the general public. Indications, dose, contraindications, sideeffects, interactions, cautions, warnings and other safety information for aztreonam. Diflucan tablets contain 50 mg, 100 mg, 150 mg, or 200 mg of fluconazole and the following inactive ingredients. Each pharmacy bulk package contains vancomycin hydrochloride equivalent to 5 grams of vancomycin base.
This emedtv page offers other important azactam warnings and precautions, including details on other possible side effects and who should not use the medicine. Aztreonam is excreted in human milk so consideration should be given to temporary discontinuation of nursing and use of formula feedings. For pseudomonas aeruginosa, a single 2 g intravenous dose produces. Twist tip ofdiluentampule and squeeze contents into glass aztreonamvial. Capitals indicate lifethreatening, underlines indicate most frequent. The monobactams, having a unique monocyclic betalactam nucleus, are structurally different from other betalactam antibiotics eg. These highlights do not include all the information needed to use tamiflu safely and effectively. Dailymed aztreonam injection, powder, lyophilized, for solution. Azactam in the galaxy plastic container pl 2040 is a frozen, isoosmotic, sterile, sodiumfree, nonpyrogenic intravenous solution. Route onset peak duration aztreonam aztreeohnam azactam.
Each 1 gram vial contains 1 gram aztreonam with approximately 780 mg arginine. Tamiflu reduce to 30oseltamivir phosphate capsules, for oral use. Single 30minute intravenous infusions of 500 mg, 1g and 2 g doses of aztreonam for injection in healthy subjects produced aztreonam peak serum levels of 54, 90 and. Asmanex twisthaler 220 mcg delivers 200 mcg mometasone furoate per actuation from the mouthpiece. Azactam for injection, 500 mgvial, 1 gvial, and 2 gvial. Azactam aztreonam for injection, usp contains the active ingredient aztreonam, a monobactam.
Aztreonam reference guide for safe and effective use from the. Sterile vancomycin hydrochloride, usp is a lyophilized powder, for preparing intravenous iv infusions. Aztreonam for injection usp, 500 mgvial, 1 gvial, and 2 gvial fda. Bactroban cream mupirocin calcium cream, 2% contains the dihydrate crystalline.
Aztreonam is an antibiotic and a member of the family of medicines called. Azactamisoosmotic dextrose solution, piggyback premix. This emedtv web selection offers an indepth look at this medication, including specific uses, possible side effects, dosing information, and more. Azactam is a sterile, nonpyrogenic, sodiumfree, white powder containing approximately 780 mg arginine per gram of aztreonam. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. This medication is usually given by injection into a vein or a muscle as directed by your doctor. Azactam is available in two strengths and each vial contains either 1g or 2g aztreonam as a powder for solution for injection or infusion. Azactam aztreonam injection prescribing information. The diluted solution must have a final dalbavancin concentration of 1 mgml to 5 mgml. Asmanex twisthaler 110 mcg delivers 100 mcg mometasone furoate per actuation from the mouthpiece. Administer immediately after reconstitution using altera nebulizer system. Azactam aztreonam for injection, usp package insert. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Discard any unused portion of the reconstituted solution.
Dec 06, 2019 the serum levels of aztreonam following single 500 mg or 1 g intramuscular or intravenous or 2 g intravenous doses of azactam exceed the mic 90 for neisseria sp. Unchanged aztreonam and the inactive betalactam ring hydrolysis product of aztreonam were present in feces and urine. Fluconazole is a white crystalline solid which is slightly soluble in water and saline. It is not meant to take the place of your doctors instructions. Azactam is indicated for the treatment of the following infections caused by susceptible gramnegative microorganisms. If the contents of a 15 ml capacity vial are to be transferred to an appropriate infusion solution, each gram of aztreonam should be initially constituted with at least 3 ml sterile water for injection, usp. Aseptically transfer the required dose of reconstituted dalbavancin solution from the vials to an intravenous bag or bottle containing 5% dextrose injection, usp. Unasyn should be administered by slow intravenous injection over at least 1015 minutes or can also be delivered in greater dilutions with 50100 ml of a compatible diluent as an intravenous infusion over 1530 minutes. Food and drug administration, center for drug evaluation and research. Intravenous or intramuscular administration of a single 500 mg or 1 g dose of aztreonam for injection every 8 hours for 7 days to healthy subjects produced no apparent accumulation of aztreonam or modification of its disposition. This leaflet contains important information about diflucan dyeflewkan.
Highlights of prescribing information these highlights do not. Lexiscan regadenoson injection is a pharmacologic stress agent indicated for radionuclide myocardial perfusion imaging mpi in patients unable to undergo adequate exercise stress. The monobactams, having a unique monocyclic betalactam nucleus, are structurally. Serious infections, including sepsis and pneumonia, have been reported in patients receiving orencia. Highlights of prescribing information hypotension, throat.
Aztreonam crosses the placenta and enters the fetal circulation. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for pyridium phenazopyridine. Pour reconstituted solution into handset of nebulizer. Each2gramvialcontains2gramsaztreonam with approximately 1. Ambisome amphotericin b liposome for injection description ambisome for injection is a sterile, nonpyrogenic lyophilized product for intravenous infusion. When reconstituted as directed each 10 ml contains 500 mg and each 20 ml contains 1 gram. In healthy subjects, aztreonam is excreted in the urine about equally by active tubular secretion and glomerular filtration. Discard product if it contains particulate matter, is cloudy, or discolored protect. Azactam definition of azactam by medical dictionary. Abelcet amphotericin b lipid complex injection description abelcet is a sterile, pyrogenfree suspension for intravenous infusion. Replacerubberstopperand swirlgentlyuntilcontents are completely dissolved. Antiinfective pregnancy risk category b action inhibits bacterial cellwall synthesis during active multiplication by binding with penicillinbinding protein 3, resulting in cellwall destruction availability inhalation solution.
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